GR_PRA1 The Progressive Retinal Atrophy(PRA) leads to a degeneration of the retina and results in blindness. Syptoms typically get more severe over time.
GR_PRA2 The Progressive Retinal Atrophy(PRA) leads to a degeneration of the retina and results in blindness. Syptoms typically get more severe over time.
Prcd-PRA The Progressive Retinal Atrophy (PRA) leads to a degeneration of the retina and results in blindness. Syptoms typically get more severe over time.
Ichthyosis (type 1 & 2) Ichthyosis is a genetic disease causing dysfunction of the keratin in the skin, which leads to the production of large, differently pigmented skin scales. Dogs which are affected by this dermatosis develop first symptoms soon after birth, which might get less severe over age.
NCL, Neuronal ceroid lipifuscinosis NCL is a neurodegenerative disease: the clinical course includes increasing levels of agitation and possible outbursts of aggression, hallucinations, hyperactivity and epileptic fits. Most animals lose their ability to coordinate everyday muscular activities. As the extent of neurodegeneration increases, all affected dogs develop psychological abnormalities and ataxia.
MD, Muscular dystrophy Dogs affected by Muscular Dystrophy show raised creatine kinase levels, muscle atrophy with contractures, hyaline myofiber degeneration with mineralization, endomysial and perimysial fibrosis with fatty infiltration, and cardiomyopathy. Syptoms might show as whole body muscular weakness and clumsy motion.
Osteogenesis imperfecta Osteogenesis imperfecta is characterized by extremely fragile bones and teeths due to defects in the structure of collagen I. First symptoms appear already at young age.
MH, Maligant hyperthermia Maligant hyperthermia (MH) is an inherited disorder of skeletal muscle characterized by hypercarbia, rhabdomyolysis, generalized skeletal muscle contracture, cardiac dysrhythmia, and renal failure.
SLC, Hyperuricosuria Hyperuricosuria and Hyperuricemia cause congenitally changes in the purine metabolism . The changed metabolism might lead to formation of uric acid crystals. Preventative, affected dogs should get a low purine diet. Additionally, adequate hydration is vital.
CMS, Congenital myasthenic syndrome Symptoms of the disease are most of all a generalized skeletal muscle weakness, which worsens especially after exercise, stress or excitement. Signs can already be seen at just two weeks of age. Mobility and spinal reflexes of all limbs are reduced.
DM exon2, Degenerative myelopathy exon 2 Canine degenerative myelopathy (DM) is a fatal, slowly progressing neuro degenerative disease with a late onset (age 8 years or older). The initial clinical sign is characterised by spastic and general proprioceptive ataxia of the hind limbs. As the disease progresses, the frequently observed asymmetric weakness ascends to affect the thoracic limbs, resulting in paraplegia. Hyporeflexia of the myotatic and withdrawal reflexes occur.
CDDY and IVDD risk, Chondrodysplasia and -dystrophy In many dog breeds, Chondrodystrophy (CDDY) and/or Chondrodysplasia (CDPA) cause a short leg phenotype. However, CDDY is associated with a high risk of premature degeneration of the invertebral discs (Hansens type I intervertebral disc disease, IVDD). CDPA is inherited in an autosomal dominant manner and especially known in short-legged breeds. Regarding the length of the legs, CDDY is inherited as semi dominant trait. This means that heterozygous dogs have shorter legs than dogs tested as free, while affected dogs show a more drastic reduction of the leg length than heterozygous dogs. The risk for IVDD is inherited in a dominant manner, therefore one copy of the variation is sufficient to predispose dogs to IVDD.